Myocardial Stiffness in Patients with Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin Running title: Zile et al.; Stiffness in HFpEF
نویسندگان
چکیده
Division of Cardiology, Dept of Medicine, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, SC; Division of Cardiothoracic Surgery, Dept of Surgery, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, SC; Dept of Public Health Sciences, Medical University of South Carolina, Charleston, SC; Dept of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ; Cardiology Unit, Dept of Medicine, University of Vermont, Burlington, VT; Dept of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT; Division of Cardiology, Mayo Clinic, Rochester, MN; Division of Cardiothoracic Surgery, Dept of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT
منابع مشابه
Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin.
BACKGROUND The purpose of this study was to determine whether patients with heart failure and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness and the extent to which discovered changes depend on changes in extracellular matrix fibrillar collagen and cardiomyocyte titin. METHODS AND RESULTS Seventy patients undergoing coronary artery bypass grafting under...
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H igh myocardial diastolic stiffness has usually been attributed to excessive myocardial collagen deposition. Over the last decennium, stiff cardiomyocytes were also identified as important contributors to high myocardial diastolic stiffness , especially in heart failure (HF) with preserved ejection fraction (HFPEF). Cardiomyocyte stiffness relates to elasticity of the giant cytoskeletal protei...
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Patients with heart failure with preserved ejection fraction (HFpEF) have an increased mortality and morbidity similar to patients with systolic heart failure and reduced ejection fraction.1 The incidence of HFpEF is increasing,2 and roughly 30% to 50% of all patients with heart failure have a normal ejection fraction.3 The underlying pathophysiology is increased left ventricular diastolic stif...
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Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is frequently associated with metabolic risk factors. Patients with HFpEF have only a slightly lower mortality than patients with HF and reduced EF. The pathophysiology of HFpEF is currently incompletely understood, which precludes specific therapy. Both HF phenotypes demonstrate distinct cardiac remodeling processes...
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I ncidence and prevalence of heart failure (HF) with preserved ejection fraction (HFpEF) is rising, with half of all HF patients having a preserved left ventricular ejection fraction (LVEF). These patients have similar mortality rates as patients with HF and reduced EF (HFrEF). HFpEF is observed predominantly in the elderly with a high burden of comorbidities that may contribute to the disease ...
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